Pediatric Cardiac Genomics Consortium (U01 - Clinical Trial Not Allowed) | RFA HL 20 015

Opportunity Information: Apply for RFA HL 20 015

The Pediatric Cardiac Genomics Consortium (PCGC) grant opportunity (RFA-HL-20-015) is a National Institutes of Health (NIH) cooperative agreement (U01) that supports sites applying to serve as Research Centers within the PCGC, a multi-center collaboration focused on congenital heart disease (CHD). The central goal of the consortium is to discover and validate genetic causes of human CHD and to connect genetic variation in affected patients to clinical outcomes. In practice, this means building and studying well-characterized patient cohorts, generating and analyzing genomic data, and integrating genetics with detailed clinical phenotypes so the field can better understand why CHD occurs, how it progresses, and which genetic findings may predict prognosis or guide care.

A defining feature of this FOA is its emphasis on team science and coordinated, consortium-driven research rather than isolated single-site projects. Awardees are expected to collaborate across multiple centers and to contribute to shared goals, protocols, and data-sharing approaches typical of a cooperative agreement mechanism. The PCGC also explicitly situates itself within the larger Bench to Bassinet (B2B) Program, which connects discovery and clinical research efforts across the translational spectrum. Through B2B, the PCGC works in close coordination with the Cardiovascular Development Data Resource Center (CDDRC) and the Pediatric Heart Network (PHN), creating a pipeline that links genetic discovery, mechanistic and developmental insights, and clinically relevant outcomes research.

The FOA encourages applications from sites that are not currently part of the PCGC, with an explicit invitation to propose new directions that could expand or strengthen the consortium. This suggests NIH interest in bringing in additional expertise, patient populations, analytic capabilities, or novel research angles that complement existing PCGC efforts. While the opportunity is genomics-centered, the stated mission makes clear that success depends on tying genetic findings to rigorous clinical characterization and longitudinal outcomes, which often requires strong clinical networks, access to pediatric cardiology populations, and the ability to harmonize data across institutions.

This is labeled "Clinical Trial Not Allowed," meaning the funded activities are not intended to be prospective interventional clinical trials that assign participants to interventions to evaluate health outcomes. The work is instead oriented toward genetic discovery, observational research, data generation and analysis, and translation of genomic findings into clinically meaningful interpretations and correlations, consistent with large-scale consortium science.

Eligibility is broad and includes many types of U.S.-based organizations and governmental entities. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations (other than federally recognized tribal governments); public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other eligible entities. The FOA also highlights a range of institution types that are encouraged or explicitly included among eligible applicants, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions.

Foreign eligibility is limited in a way that is common for NIH opportunities that require a U.S. hub. Non-domestic (non-U.S.) entities and non-U.S. institutions are not eligible to apply as the applicant organization. However, non-domestic components of U.S. organizations may participate, and foreign components are allowed as defined in the NIH Grants Policy Statement, which generally means a U.S. applicant can include certain foreign activities or collaborations when they are well-justified and meet NIH policy requirements.

Administrative details in the source listing note that the sponsoring agency is NIH, the opportunity category is discretionary, and the activity category is health (CFDA 93.837). The original closing date shown is October 2, 2019, indicating this particular announcement was tied to that submission cycle. The listed award ceiling is $275,000, and the instrument type is a cooperative agreement, which typically implies substantial NIH programmatic involvement in coordinating consortium goals, milestones, and governance compared with a standard research grant.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Pediatric Cardiac Genomics Consortium (U01 - Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.837.
• This funding opportunity was created on 2019-06-06.
• Applicants must submit their applications by 2019-10-02. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $275,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA HL 20 015

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