Opportunity Information: Apply for RFA HD 24 010
The National Centers for Translational Research in Reproduction and Infertility (NCTRI) funding opportunity is a National Institutes of Health (NIH) program run by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), specifically through its Fertility and Infertility (FI) Branch. It supports a limited number of specialized, multidisciplinary research centers focused on reproductive science, reproduction, and infertility. The centers are meant to bring basic (laboratory) researchers and clinical investigators into the same organized program so they can build strong translational pipelines, meaning discoveries can move from bench to bedside and, just as importantly, clinical observations can guide new laboratory work. The overall intent is to improve human reproductive health by accelerating practical, clinically meaningful advances through research excellence, coordination, and innovation.
This announcement is a re-competition of the existing NCTRI program, meaning NICHD is renewing and recompeting the network of centers rather than starting an entirely new concept. Awards are made using the P50 Specialized Research Center mechanism, which is designed for large, multi-project center grants rather than single-project research awards. The opportunity is labeled "Clinical Trial Optional," which generally means applicants may propose clinical trials if they are scientifically justified, but clinical trials are not required for a competitive application. The NCTRI program is structured as a national network, so beyond funding the work at each individual center, NICHD is explicitly encouraging collaboration and coordination across sites to speed progress, share expertise, and standardize or align approaches where it helps the field.
Eligibility is broad and includes many types of U.S.-based organizations and government entities. Eligible applicants include state, county, and city/township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations with or without 501(c)(3) status (as long as they are not institutions of higher education); for-profit organizations (other than small businesses) and small businesses; public housing authorities/Indian housing authorities; and Native American tribal governments (federally recognized) as well as Native American tribal organizations that are not federally recognized tribal governments. The notice also explicitly calls out additional eligible applicant types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), along with faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions.
Foreign eligibility is limited in a way that is typical for NIH center programs. Non-domestic (non-U.S.) entities and non-domestic (non-U.S.) institutions are not eligible to apply as the primary applicant organization, and non-domestic components of U.S. organizations are also not eligible to apply. However, "foreign components" are allowed as defined in the NIH Grants Policy Statement, which usually means a U.S. applicant can include certain project activities performed outside the U.S. when there is a strong scientific justification and when the arrangement meets NIH policy requirements. In practice, this is often used when unique populations, specimens, expertise, or resources exist outside the U.S. and are important to the research goals, while the main center remains U.S.-based and led.
Key administrative details in the source information include the Funding Opportunity Number RFA-HD-24-010 and a creation date of August 17, 2023. The original closing date listed is November 29, 2023. The award is categorized as a discretionary grant in the Health, Income Security and Social Services activity area, under CFDA 93.865. The listed award ceiling is $1,100,000, which is commonly interpreted as an annual cap per award unless otherwise specified in the full funding announcement (the detailed NOFO typically clarifies whether this is per year, direct costs versus total costs, and how budgets should be structured across multiple projects and cores within a P50).
In practical terms, the program is looking for center applications that convincingly show how an integrated team will tackle important problems in reproduction and infertility with a translational focus, how the center will create meaningful interaction between basic and clinical disciplines, and how its structure will support productivity beyond what separate individual grants could do. Because the centers are intended to operate as a coordinated national network, competitive applications usually need to demonstrate not only strong science and leadership locally, but also a clear plan and willingness to engage with the broader NCTRI community to amplify impact across the field.Apply for RFA HD 24 010
- The National Institutes of Health in the health, income security and social services sector is offering a public funding opportunity titled "National Centers for Translational Research in Reproduction and Infertility (NCTRI) (P50 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865.
- This funding opportunity was created on 2023-08-17.
- Applicants must submit their applications by 2023-11-29. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,100,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the NCTRI funding opportunity?
The National Centers for Translational Research in Reproduction and Infertility (NCTRI) is a National Institutes of Health (NIH) program run by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), through its Fertility and Infertility (FI) Branch. It supports a limited number of specialized, multidisciplinary research centers focused on reproductive science, reproduction, and infertility.
What is the main goal of NCTRI?
The intent is to improve human reproductive health by accelerating practical, clinically meaningful advances. The program emphasizes research excellence, coordination, and innovation, with a strong translational focus so discoveries can move from bench to bedside and clinical observations can guide new laboratory research.
What does "translational" mean in the context of this program?
In this program, translational research means creating strong two-way pipelines between basic (laboratory) research and clinical investigation. Laboratory discoveries should be positioned to inform patient-oriented advances, and clinical findings should be used to shape and refine laboratory research questions and approaches.
What type of grant mechanism does NCTRI use?
Awards are made using the P50 Specialized Research Center mechanism. This mechanism is designed for large, multi-project center grants (not a single-project research award) and typically supports multiple integrated research projects and shared cores within an organized center structure.
Is this a new program or a renewal of an existing program?
This announcement is a re-competition of the existing NCTRI program. That means NICHD is renewing and recompeting the network of centers rather than launching an entirely new concept.
Are clinical trials required?
No. The opportunity is labeled "Clinical Trial Optional." Applicants may propose clinical trials if they are scientifically justified, but proposing a clinical trial is not required for a competitive application based on the information provided.
What kinds of research centers is NICHD looking to fund?
The program is looking for center applications that show a convincing plan for an integrated team to tackle important problems in reproduction and infertility with a translational focus. A strong application typically demonstrates meaningful interaction between basic and clinical disciplines and a structure that supports productivity beyond what separate individual grants could achieve.
How important is collaboration across different funded centers?
Collaboration is a central feature. NCTRI is structured as a national network, and NICHD is explicitly encouraging coordination and collaboration across sites to speed progress, share expertise, and align or standardize approaches where it benefits the field.
Who is the sponsoring NIH institute and program area?
The sponsoring institute is NICHD (Eunice Kennedy Shriver National Institute of Child Health and Human Development), and it is administered through NICHD's Fertility and Infertility (FI) Branch.
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number listed is RFA-HD-24-010.
What is the creation date of this opportunity?
The creation date listed is August 17, 2023.
What is the closing date listed in the provided information?
The original closing date listed is November 29, 2023.
What is the CFDA number and activity area?
The CFDA number provided is 93.865. The award is categorized as a discretionary grant in the Health, Income Security and Social Services activity area.
What is the award ceiling for this opportunity?
The listed award ceiling is $1,100,000. Based on the information provided, this is commonly interpreted as an annual cap per award unless the full funding announcement specifies otherwise (for example, whether the cap is per year, whether it is direct costs versus total costs, and how budgets should be structured across multiple projects and cores within a P50).
Which U.S. organizations are eligible to apply?
Eligibility is broad and includes many U.S.-based organizations and government entities. Eligible applicants include state, county, and city/township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations with or without 501(c)(3) status (as long as they are not institutions of higher education); for-profit organizations (other than small businesses) and small businesses; public housing authorities/Indian housing authorities; and Native American tribal governments (federally recognized) as well as Native American tribal organizations that are not federally recognized tribal governments.
Are minority-serving institutions specifically included as eligible applicants?
Yes. The notice explicitly calls out eligibility for Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs).
Are faith-based or community-based organizations eligible?
Yes. The information provided explicitly includes faith-based or community-based organizations among eligible applicant types.
Are federal agencies eligible to apply?
Yes. Eligible federal agencies are explicitly listed among eligible applicant types.
Are U.S. territories or possessions eligible to apply?
Yes. U.S. territories or possessions are explicitly included among eligible applicant types.
Can a non-U.S. (foreign) organization apply as the primary applicant?
No. Non-domestic (non-U.S.) entities and non-domestic institutions are not eligible to apply as the primary applicant organization for this opportunity.
Are non-U.S. components of U.S. organizations eligible to apply?
No. Non-domestic components of U.S. organizations are also not eligible to apply as the applicant organization.
Can a U.S. applicant include work performed outside the United States?
Yes, in a limited way. "Foreign components" are allowed as defined in the NIH Grants Policy Statement. This generally means a U.S. applicant may include certain project activities performed outside the U.S. when there is strong scientific justification and when the arrangement meets NIH policy requirements.
When might a foreign component be justified?
Based on the information provided, a foreign component is often used when unique populations, specimens, expertise, or resources exist outside the U.S. and are important to the research goals, while the main center remains U.S.-based and led.
What is the intended structure and value of an NCTRI center compared to separate grants?
The centers are intended to integrate basic and clinical investigators within the same organized program and to support productivity and impact beyond what separate individual grants could accomplish. This includes coordinated leadership, intentional cross-disciplinary interaction, and network-level engagement with other centers.
What should a competitive application demonstrate at a high level?
Based on the description provided, competitive applications generally need to demonstrate strong science and leadership locally, a clear translational strategy linking laboratory and clinical work, an effective center structure suited to a P50, and a plan and willingness to collaborate with the broader NCTRI network to amplify field-wide impact.
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