Limited Competition: Childhood Cancer Survivor Study (U24 Clinical Trial Required) | RFA CA 20 052

Opportunity Information: Apply for RFA CA 20 052

This funding opportunity, titled "Limited Competition: Childhood Cancer Survivor Study (U24 Clinical Trial Required)" (RFA-CA-20-052), is a National Institutes of Health (NIH) cooperative agreement designed to continue support for the Childhood Cancer Survivor Study (CCSS). The core goal is to sustain CCSS as a shared national resource that enables a wide range of research on the long-term and late effects of childhood and adolescent cancer and the therapies used to treat it. In practical terms, the award is meant to keep the infrastructure, coordination, and research capabilities of CCSS operating so investigators can better understand how earlier cancer treatments influence survivors health decades later, including medical complications, quality of life issues, and other lasting outcomes.

CCSS itself is described as a large, multi-institutional collaborative cohort that already follows more than 25,000 individuals who survived at least five years after being diagnosed with childhood cancer between 1970 and 1999. The study also includes over 5,000 sibling control participants, which strengthens research findings by providing a comparison group with similar family and environmental backgrounds. By maintaining and expanding this cohort-based resource, the program supports broad scientific use, including studies that connect historical treatment exposures to later health risks across the lifespan of survivors.

The award mechanism is a U24 cooperative agreement, which generally indicates a substantial, ongoing partnership between the NIH and the awardee rather than a hands-off grant. This FOA is labeled a limited competition, meaning it is not a fully open call to the entire research community in the usual sense; it is intended to fund continued operation of a specific, established resource. The activity area is within Education and Health, and it is tied to CFDA number 93.395. The listing also specifies "Clinical Trial Required," which in NIH terminology typically signals that the supported program is expected to include clinical trial activity or clinical research that meets NIH definitions, even if the broader CCSS mission is resource and infrastructure driven.

Eligibility is broad across many U.S.-based organization types, including state, county, city, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding higher education institutions in those particular categories); for-profit organizations other than small businesses; and small businesses. The FOA explicitly highlights additional eligible applicant categories often emphasized in NIH opportunities, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.

At the same time, the FOA makes important distinctions about non-U.S. participation. Non-domestic (non-U.S.) entities and non-domestic institutions are not eligible to apply as the applicant organization. However, non-domestic components of U.S. organizations are eligible, and foreign components, as defined by the NIH Grants Policy Statement, are allowed. This setup allows certain international collaborations or activities under a U.S.-led application, while keeping the prime award anchored in an eligible U.S. applicant institution.

Key administrative details included in the source information are that the sponsoring agency is NIH, the opportunity category is discretionary, and the original closing date was November 18, 2020, with a creation date of August 13, 2020. The award ceiling and expected number of awards are not specified in the provided data, which is sometimes the case in listings where final budgets or award counts depend on appropriations, negotiations, or programmatic decisions. Overall, the opportunity centers on sustaining a major survivorship cohort and its supporting infrastructure so researchers can continue generating evidence about long-term outcomes of pediatric and adolescent cancer and informing follow-up care, screening practices, and survivorship guidelines.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Limited Competition: Childhood Cancer Survivor Study (U24 Clinical Trial Required)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.395.
• This funding opportunity was created on 2020-08-13.
• Applicants must submit their applications by 2020-11-18. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA CA 20 052

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